ORCHARD THERAPEUTICS PLC

CUSIP: 68570P101 Class: ADS

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2022
Shares 21,905 Value ($000) $8 Avg Close — Range —
Q3 2022
Shares 36,591 Value ($000) $18 Avg Close — Range —
Q2 2022
Shares 20,035 Value ($000) $12 Avg Close — Range —
Q4 2021
Shares 542,212 Value ($000) $716 Avg Close — Range —
Q1 2021
Shares 19,683 Value ($000) $143 Avg Close — Range —
Q4 2020
Shares 93,932 Value ($000) $406 Avg Close — Range —
Q2 2020
Shares 72,752 Value ($000) $437 Avg Close — Range —
Q1 2020
Shares 53,015 Value ($000) $399 Avg Close — Range —
Q4 2019
Shares 21,687 Value ($000) $298 Avg Close — Range —