ORCHARD THERAPEUTICS PLC

CUSIP: 68570P101 Class: ADS

TWO SIGMA SECURITIES, LLC's Holding History (CIK: 0001450144)

Note: Option positions (PUT/CALL) are excluded.

Q4 2022
Shares 25,359 Value ($000) $9 Avg Close — Range —
Q3 2022
Shares 13,825 Value ($000) $7 Avg Close — Range —
Q4 2021
Shares 46,311 Value ($000) $61 Avg Close — Range —