ORCHARD THERAPEUTICS PLC

CUSIP: 68570P101 Class: ADS

TWO SIGMA ADVISERS, LP's Holding History (CIK: 0001478735)

Note: Option positions (PUT/CALL) are excluded.

Q4 2022
Shares 21,100 Value ($000) $8 Avg Close — Range —
Q3 2022
Shares 19,500 Value ($000) $10 Avg Close — Range —
Q1 2022
Shares 15,900 Value ($000) $11 Avg Close — Range —
Q4 2021
Shares 189,700 Value ($000) $250 Avg Close — Range —
Q4 2020
Shares 15,900 Value ($000) $69 Avg Close — Range —
Q2 2020
Shares 11,500 Value ($000) $69 Avg Close — Range —
Q1 2020
Shares 23,000 Value ($000) $173 Avg Close — Range —