OREXIGEN THERAPEUTICS INC

CUSIP: 686164104 Class: COMMON STOCK

PRICE T ROWE ASSOCIATES INC /MD/'s Holding History (CIK: 0000080255)

Note: Option positions (PUT/CALL) are excluded.

Q4 2015
Shares 6,508,415 Value ($000) $11,194 Avg Close — Range —
Q3 2015
Shares 6,491,715 Value ($000) $13,698 Avg Close — Range —
Q2 2015
Shares 6,583,700 Value ($000) $32,589 Avg Close — Range —
Q1 2015
Shares 6,612,800 Value ($000) $51,778 Avg Close — Range —
Q4 2014
Shares 6,665,200 Value ($000) $40,391 Avg Close — Range —
Q3 2014
Shares 8,145,200 Value ($000) $34,699 Avg Close — Range —
Q2 2014
Shares 4,786,400 Value ($000) $29,580 Avg Close — Range —
Q1 2014
Shares 2,634,512 Value ($000) $17,124 Avg Close — Range —
Q4 2013
Shares 44,600 Value ($000) $251 Avg Close — Range —
Q3 2013
Shares 14,800 Value ($000) $91 Avg Close — Range —
Q2 2013
Shares 865,700 Value ($000) $5,064 Avg Close — Range —