OREXIGEN THERAPEUTICS INC

CUSIP: 686164104 Class: COMMON STOCK

ESSEX INVESTMENT MANAGEMENT CO LLC's Holding History (CIK: 0000201772)

Note: Option positions (PUT/CALL) are excluded.

Q1 2014
Shares 433,657 Value ($000) $2,819 Avg Close — Range —
Q4 2013
Shares 544,779 Value ($000) $3,067 Avg Close — Range —
Q3 2013
Shares 585,445 Value ($000) $3,589 Avg Close — Range —
Q2 2013
Shares 613,560 Value ($000) $3,586 Avg Close — Range —