OREXIGEN THERAPEUTICS INC

CUSIP: 686164104 Class: COMMON STOCK

FMR LLC's Holding History (CIK: 0000315066)

Note: Option positions (PUT/CALL) are excluded.

Q1 2016
Shares 7,412,756 Value ($000) $4,171 Avg Close — Range —
Q4 2015
Shares 11,598,705 Value ($000) $19,950 Avg Close — Range —
Q3 2015
Shares 11,598,705 Value ($000) $24,473 Avg Close — Range —
Q2 2015
Shares 11,598,705 Value ($000) $57,414 Avg Close — Range —
Q1 2015
Shares 10,894,205 Value ($000) $85,302 Avg Close — Range —
Q4 2014
Shares 10,613,981 Value ($000) $64,321 Avg Close — Range —
Q3 2014
Shares 10,130,881 Value ($000) $43,158 Avg Close — Range —
Q2 2014
Shares 9,921,581 Value ($000) $61,315 Avg Close — Range —
Q1 2014
Shares 6,911,881 Value ($000) $44,927 Avg Close — Range —
Q4 2013
Shares 3,087,551 Value ($000) $17,383 Avg Close — Range —
Q3 2013
Shares 5,449,951 Value ($000) $33,463 Avg Close — Range —
Q2 2013
Shares 3,614,051 Value ($000) $21,142 Avg Close — Range —