OREXIGEN THERAPEUTICS INC

CUSIP: 686164104 Class: COMMON STOCK

FIL Ltd's Holding History (CIK: 0000318989)

Note: Option positions (PUT/CALL) are excluded.

Q4 2015
Shares 588,240 Value ($000) $1,012 Avg Close — Range —
Q3 2015
Shares 1,586,888 Value ($000) $3,348 Avg Close — Range —
Q2 2015
Shares 1,663,581 Value ($000) $8,235 Avg Close — Range —
Q1 2015
Shares 1,697,014 Value ($000) $13,287 Avg Close — Range —
Q4 2014
Shares 1,083,041 Value ($000) $6,563 Avg Close — Range —
Q3 2014
Shares 1,083,041 Value ($000) $4,614 Avg Close — Range —
Q2 2014
Shares 2,259,500 Value ($000) $13,964 Avg Close — Range —
Q1 2014
Shares 2,206,701 Value ($000) $14,344 Avg Close — Range —
Q4 2013
Shares 1,505,486 Value ($000) $8,476 Avg Close — Range —
Q3 2013
Shares 437,800 Value ($000) $2,688 Avg Close — Range —