OREXIGEN THERAPEUTICS INC

CUSIP: 686164104 Class: COMMON STOCK

FIRST MANHATTAN CO. LLC.'s Holding History (CIK: 0000728083)

Note: Option positions (PUT/CALL) are excluded.

Q2 2016
Shares 20,000 Value ($000) $8 Avg Close — Range —
Q1 2016
Shares 20,000 Value ($000) $11 Avg Close — Range —
Q4 2015
Shares 20,000 Value ($000) $34 Avg Close — Range —
Q3 2015
Shares 21,000 Value ($000) $44 Avg Close — Range —
Q2 2015
Shares 20,000 Value ($000) $99 Avg Close — Range —
Q1 2015
Shares 20,000 Value ($000) $156 Avg Close — Range —
Q4 2014
Shares 20,000 Value ($000) $121 Avg Close — Range —
Q3 2014
Shares 10,000 Value ($000) $42 Avg Close — Range —
Q2 2014
Shares 2,810,055 Value ($000) $17,366 Avg Close — Range —
Q1 2014
Shares 4,210,055 Value ($000) $27,365 Avg Close — Range —
Q4 2013
Shares 4,961,790 Value ($000) $27,934 Avg Close — Range —
Q3 2013
Shares 5,247,990 Value ($000) $32,170 Avg Close — Range —
Q2 2013
Shares 6,141,636 Value ($000) $46,860 Avg Close — Range —