OREXIGEN THERAPEUTICS INC

CUSIP: 686164104 Class: COMMON STOCK

MANUFACTURERS LIFE INSURANCE COMPANY, THE's Holding History (CIK: 0000928047)

Note: Option positions (PUT/CALL) are excluded.

Q1 2016
Shares 72,654 Value ($000) $41 Avg Close — Range —
Q4 2015
Shares 604,684 Value ($000) $1,040 Avg Close — Range —
Q3 2015
Shares 491,859 Value ($000) $1,038 Avg Close — Range —
Q2 2015
Shares 66,820 Value ($000) $331 Avg Close — Range —
Q1 2015
Shares 81,501 Value ($000) $638 Avg Close — Range —
Q4 2014
Shares 78,544 Value ($000) $476 Avg Close — Range —
Q3 2014
Shares 80,424 Value ($000) $342 Avg Close — Range —
Q2 2014
Shares 73,533 Value ($000) $455 Avg Close — Range —
Q1 2014
Shares 76,076 Value ($000) $494 Avg Close — Range —
Q4 2013
Shares 72,575 Value ($000) $409 Avg Close — Range —
Q3 2013
Shares 74,878 Value ($000) $459 Avg Close — Range —
Q2 2013
Shares 77,809 Value ($000) $455 Avg Close — Range —