OREXIGEN THERAPEUTICS INC

CUSIP: 686164104 Class: COMMON STOCK

D. E. Shaw & Co., Inc.'s Holding History (CIK: 0001009207)

Note: Option positions (PUT/CALL) are excluded.

Q4 2015
Shares 22,293 Value ($000) $38 Avg Close — Range —
Q3 2015
Shares 97,735 Value ($000) $206 Avg Close — Range —
Q2 2015
Shares 239,648 Value ($000) $1,186 Avg Close — Range —
Q1 2015
Shares 822,562 Value ($000) $6,441 Avg Close — Range —
Q4 2014
Shares 736,821 Value ($000) $4,465 Avg Close — Range —
Q3 2014
Shares 1,017,360 Value ($000) $4,334 Avg Close — Range —
Q2 2014
Shares 852,313 Value ($000) $5,267 Avg Close — Range —
Q1 2014
Shares 721,088 Value ($000) $4,687 Avg Close — Range —
Q4 2013
Shares 1,548,176 Value ($000) $8,716 Avg Close — Range —
Q3 2013
Shares 1,398,910 Value ($000) $8,589 Avg Close — Range —
Q2 2013
Shares 1,394,277 Value ($000) $8,156 Avg Close — Range —