OREXIGEN THERAPEUTICS INC

CUSIP: 686164104 Class: COMMON STOCK

ADAGE CAPITAL PARTNERS GP, L.L.C.'s Holding History (CIK: 0001165408)

Note: Option positions (PUT/CALL) are excluded.

Q2 2015
Shares 1,000,000 Value ($000) $4,950 Avg Close — Range —
Q4 2013
Shares 391,100 Value ($000) $2,202 Avg Close — Range —
Q3 2013
Shares 678,800 Value ($000) $4,161 Avg Close — Range —
Q2 2013
Shares 876,000 Value ($000) $5,120 Avg Close — Range —
Q1 2013
Shares 1,200,000 Value ($000) $7,512 Avg Close — Range —