OREXIGEN THERAPEUTICS INC

CUSIP: 686164104 Class: COMMON STOCK

Palo Alto Investors LP's Holding History (CIK: 0001306923)

Note: Option positions (PUT/CALL) are excluded.

Q2 2016
Shares 1,673,024 Value ($000) $719 Avg Close — Range —
Q1 2016
Shares 1,673,024 Value ($000) $941 Avg Close — Range —
Q4 2015
Shares 1,673,024 Value ($000) $2,878 Avg Close — Range —
Q3 2015
Shares 1,931,324 Value ($000) $4,075 Avg Close — Range —
Q2 2015
Shares 1,931,324 Value ($000) $9,560 Avg Close — Range —
Q1 2015
Shares 1,931,324 Value ($000) $15,122 Avg Close — Range —
Q4 2014
Shares 1,931,324 Value ($000) $11,704 Avg Close — Range —
Q3 2014
Shares 1,931,324 Value ($000) $8,227 Avg Close — Range —
Q2 2014
Shares 1,931,324 Value ($000) $11,936 Avg Close — Range —
Q1 2014
Shares 1,669,024 Value ($000) $10,849 Avg Close — Range —