OREXIGEN THERAPEUTICS INC

CUSIP: 686164104 Class: COMMON STOCK

SIMPLEX TRADING, LLC's Holding History (CIK: 0001488542)

Note: Option positions (PUT/CALL) are excluded.

Q2 2016
Shares 5,193 Value ($000) $2 Avg Close — Range —
Q1 2016
Shares 12,093 Value ($000) $6 Avg Close — Range —
Q4 2015
Shares 799 Value ($000) $1 Avg Close — Range —
Q1 2015
Shares 2,609 Value ($000) $20 Avg Close — Range —
Q4 2014
Shares 13,111 Value ($000) $79 Avg Close — Range —