OREXIGEN THERAPEUTICS INC

CUSIP: 686164104 Class: COMMON STOCK

Swiss National Bank's Holding History (CIK: 0001582202)

Note: Option positions (PUT/CALL) are excluded.

Q1 2016
Shares 221,800 Value ($000) $120 Avg Close — Range —
Q4 2015
Shares 145,600 Value ($000) $250 Avg Close — Range —
Q3 2015
Shares 145,600 Value ($000) $307 Avg Close — Range —
Q2 2015
Shares 125,500 Value ($000) $621 Avg Close — Range —
Q1 2015
Shares 121,100 Value ($000) $948 Avg Close — Range —
Q4 2014
Shares 121,100 Value ($000) $734 Avg Close — Range —
Q3 2014
Shares 113,900 Value ($000) $485 Avg Close — Range —
Q2 2014
Shares 104,900 Value ($000) $648 Avg Close — Range —
Q1 2014
Shares 104,900 Value ($000) $682 Avg Close — Range —
Q4 2013
Shares 81,000 Value ($000) $456 Avg Close — Range —
Q3 2013
Shares 78,200 Value ($000) $480 Avg Close — Range —
Q2 2013
Shares 73,100 Value ($000) $428 Avg Close — Range —