OREXIGEN THERAPEUTICS INC

CUSIP: 686164302 Class: Stock

TWO SIGMA SECURITIES, LLC's Holding History (CIK: 0001450144)

Note: Option positions (PUT/CALL) are excluded.

Q4 2016
Shares 22,934 Value ($000) $40 Avg Close — Range —
Q3 2016
Shares 10,478 Value ($000) $35 Avg Close — Range —