ORPHAZYME A S

CUSIP: 687305102 Class: ADS

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2021
Shares 141,117 Value ($000) $340 Avg Close — Range —
Q3 2021
Shares 239,937 Value ($000) $986 Avg Close — Range —