OTONOMY INC

CUSIP: 68906L105 Class: COM

ADAGE CAPITAL PARTNERS GP, L.L.C.'s Holding History (CIK: 0001165408)

Note: Option positions (PUT/CALL) are excluded.

Q2 2022
Shares 5,000,000 Value ($000) $10,400 Avg Close — Range —
Q1 2022
Shares 5,000,000 Value ($000) $12,000 Avg Close — Range —
Q4 2021
Shares 4,000,000 Value ($000) $8,320 Avg Close — Range —
Q3 2021
Shares 4,000,000 Value ($000) $7,680 Avg Close — Range —
Q2 2021
Shares 3,500,000 Value ($000) $7,805 Avg Close — Range —
Q1 2021
Shares 2,000,500 Value ($000) $5,101 Avg Close — Range —
Q4 2020
Shares 1,025,500 Value ($000) $6,635 Avg Close — Range —
Q3 2020
Shares 1,025,500 Value ($000) $4,153 Avg Close — Range —