OTONOMY INC

CUSIP: 68906L105 Class: COM

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q3 2022
Shares 142,183 Value ($000) $42 Avg Close — Range —
Q2 2022
Shares 62,030 Value ($000) $129 Avg Close — Range —
Q1 2022
Shares 160,696 Value ($000) $386 Avg Close — Range —
Q4 2021
Shares 237,285 Value ($000) $494 Avg Close — Range —
Q3 2021
Shares 380,061 Value ($000) $730 Avg Close — Range —
Q2 2021
Shares 502,312 Value ($000) $1,120 Avg Close — Range —
Q1 2021
Shares 557,049 Value ($000) $1,420 Avg Close — Range —
Q4 2020
Shares 268,731 Value ($000) $1,739 Avg Close — Range —
Q3 2020
Shares 147,598 Value ($000) $598 Avg Close — Range —
Q1 2020
Shares 27,738 Value ($000) $55 Avg Close — Range —
Q4 2019
Shares 31,339 Value ($000) $120 Avg Close — Range —
Q3 2019
Shares 47,443 Value ($000) $113 Avg Close — Range —
Q2 2019
Shares 64,685 Value ($000) $178 Avg Close — Range —
Q1 2019
Shares 69,185 Value ($000) $182 Avg Close — Range —
Q4 2018
Shares 71,763 Value ($000) $133 Avg Close — Range —
Q3 2018
Shares 76,421 Value ($000) $210 Avg Close — Range —
Q3 2017
Shares 18,000 Value ($000) $59 Avg Close — Range —
Q4 2015
Shares 7,807 Value ($000) $217 Avg Close — Range —