PACIFIC BIOSCIENCES CALIF IN

Ticker: PACB CUSIP: 69404D108 Class: COM

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 2,877,184 Value ($000) $5,380 Avg Close $1.92 Range $1.26 - $2.73

Q3 2025

Shares 401,766 Value ($000) $514 Avg Close $1.35 Range $1.15 - $1.76

Q1 2025

Shares 542,200 Value ($000) $640 Avg Close $1.53 Range $1.08 - $2.22

Q4 2024

Shares 1,113,577 Value ($000) $2,038 Avg Close $1.95 Range $1.42 - $2.72

Q3 2024

Shares 465,170 Value ($000) $791 Avg Close $1.64 Range $1.16 - $2.26

Q2 2024

Shares 835,420 Value ($000) $1,145 Avg Close $2.02 Range $1.25 - $3.85

Q1 2024

Shares 188,692 Value ($000) $708 Avg Close $5.86 Range $3.46 - $9.99

Q4 2023

Shares 73,573 Value ($000) $722 Avg Close $8.18 Range $5.74 - $10.65

Q3 2023

Shares 362,657 Value ($000) $3,028 Avg Close $11.43 Range $8.16 - $14.55

Q2 2023

Shares 764,772 Value ($000) $10,171 Avg Close $12.15 Range $9.85 - $14.30

Q1 2023

Shares 59,800 Value ($000) $692 Avg Close $9.94 Range $7.77 - $12.54

Q4 2022

Shares 59,800 Value ($000) $489 Avg Close $8.62 Range $5.46 - $12.37

Q2 2022

Shares 4,487,462 Value ($000) $19,835 Avg Close $6.08 Range $3.85 - $10.48

Q1 2022

Shares 3,088,155 Value ($000) $28,102 Avg Close $11.51 Range $8.26 - $21.01

Q4 2021

Shares 388,961 Value ($000) $7,958 Avg Close $24.13 Range $18.26 - $31.10

Q3 2021

Shares 921,612 Value ($000) $23,547 Avg Close $29.63 Range $24.31 - $35.58

Q2 2021

Shares 1,512,729 Value ($000) $52,900 Avg Close $29.09 Range $20.22 - $37.42

Q1 2021

Shares 1,414,883 Value ($000) $47,130 Avg Close $35.00 Range $24.47 - $53.69

Q2 2020

Shares 28,694 Value ($000) $99 Avg Close $3.40 Range $2.54 - $4.22

Q4 2017

Shares 140,298 Value ($000) $370 Avg Close $3.50 Range $2.51 - $5.58

Q1 2016

Shares 111,292 Value ($000) $946 Avg Close $9.83 Range $7.50 - $13.98

Q4 2014

Shares 63,466 Value ($000) $498 Avg Close $6.40 Range $4.52 - $8.10

Q3 2013

Shares 29,854 Value ($000) $165 Avg Close $3.47 Range $2.45 - $6.50

Q2 2013

Shares 26,900 Value ($000) $68 Avg Close $2.49 Range $1.95 - $2.94

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	2,877,184	$5,380	$1.92	$1.26 - $2.73
Q3 2025	401,766	$514	$1.35	$1.15 - $1.76
Q1 2025	542,200	$640	$1.53	$1.08 - $2.22
Q4 2024	1,113,577	$2,038	$1.95	$1.42 - $2.72
Q3 2024	465,170	$791	$1.64	$1.16 - $2.26
Q2 2024	835,420	$1,145	$2.02	$1.25 - $3.85
Q1 2024	188,692	$708	$5.86	$3.46 - $9.99
Q4 2023	73,573	$722	$8.18	$5.74 - $10.65
Q3 2023	362,657	$3,028	$11.43	$8.16 - $14.55
Q2 2023	764,772	$10,171	$12.15	$9.85 - $14.30
Q1 2023	59,800	$692	$9.94	$7.77 - $12.54
Q4 2022	59,800	$489	$8.62	$5.46 - $12.37
Q2 2022	4,487,462	$19,835	$6.08	$3.85 - $10.48
Q1 2022	3,088,155	$28,102	$11.51	$8.26 - $21.01
Q4 2021	388,961	$7,958	$24.13	$18.26 - $31.10
Q3 2021	921,612	$23,547	$29.63	$24.31 - $35.58
Q2 2021	1,512,729	$52,900	$29.09	$20.22 - $37.42
Q1 2021	1,414,883	$47,130	$35.00	$24.47 - $53.69
Q2 2020	28,694	$99	$3.40	$2.54 - $4.22
Q4 2017	140,298	$370	$3.50	$2.51 - $5.58
Q1 2016	111,292	$946	$9.83	$7.50 - $13.98
Q4 2014	63,466	$498	$6.40	$4.52 - $8.10
Q3 2013	29,854	$165	$3.47	$2.45 - $6.50
Q2 2013	26,900	$68	$2.49	$1.95 - $2.94