PACIFIC BIOSCIENCES CALIF IN

Ticker: PACB CUSIP: 69404D108 Class: COM

TWO SIGMA ADVISERS, LP's Holding History (CIK: 0001478735)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 827,500 Value ($000) $1,547 Avg Close $1.92 Range $1.26 - $2.73

Q2 2025

Shares 25,000 Value ($000) $31 Avg Close $1.15 Range $0.85 - $1.49

Q1 2025

Shares 102,500 Value ($000) $121 Avg Close $1.53 Range $1.08 - $2.22

Q4 2024

Shares 167,900 Value ($000) $307 Avg Close $1.95 Range $1.42 - $2.72

Q3 2024

Shares 140,100 Value ($000) $238 Avg Close $1.64 Range $1.16 - $2.26

Q2 2024

Shares 122,200 Value ($000) $167 Avg Close $2.02 Range $1.25 - $3.85

Q1 2024

Shares 144,400 Value ($000) $542 Avg Close $5.86 Range $3.46 - $9.99

Q4 2023

Shares 151,800 Value ($000) $1,489 Avg Close $8.18 Range $5.74 - $10.65

Q3 2023

Shares 174,400 Value ($000) $1,456 Avg Close $11.43 Range $8.16 - $14.55

Q2 2023

Shares 194,800 Value ($000) $2,591 Avg Close $12.15 Range $9.85 - $14.30

Q1 2023

Shares 164,600 Value ($000) $1,906 Avg Close $9.94 Range $7.77 - $12.54

Q4 2022

Shares 187,000 Value ($000) $1,530 Avg Close $8.62 Range $5.46 - $12.37

Q3 2022

Shares 983,000 Value ($000) $5,706 Avg Close $5.74 Range $3.89 - $14.20

Q2 2022

Shares 3,580,600 Value ($000) $15,826 Avg Close $6.08 Range $3.85 - $10.48

Q1 2022

Shares 1,088,300 Value ($000) $9,904 Avg Close $11.51 Range $8.26 - $21.01

Q4 2021

Shares 382,400 Value ($000) $7,824 Avg Close $24.13 Range $18.26 - $31.10

Q3 2021

Shares 560,800 Value ($000) $14,328 Avg Close $29.63 Range $24.31 - $35.58

Q2 2021

Shares 507,300 Value ($000) $17,740 Avg Close $29.09 Range $20.22 - $37.42

Q1 2021

Shares 231,800 Value ($000) $7,721 Avg Close $35.00 Range $24.47 - $53.69

Q4 2019

Shares 16,600 Value ($000) $85 Avg Close $5.08 Range $4.37 - $5.69

Q3 2019

Shares 38,600 Value ($000) $199 Avg Close $5.59 Range $4.96 - $6.21

Q2 2019

Shares 225,600 Value ($000) $1,365 Avg Close $7.01 Range $5.80 - $7.50

Q4 2017

Shares 30,700 Value ($000) $81 Avg Close $3.50 Range $2.51 - $5.58

Q3 2017

Shares 18,700 Value ($000) $98 Avg Close $4.30 Range $3.08 - $5.70

Q4 2014

Shares 72,600 Value ($000) $569 Avg Close $6.40 Range $4.52 - $8.10

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	827,500	$1,547	$1.92	$1.26 - $2.73
Q2 2025	25,000	$31	$1.15	$0.85 - $1.49
Q1 2025	102,500	$121	$1.53	$1.08 - $2.22
Q4 2024	167,900	$307	$1.95	$1.42 - $2.72
Q3 2024	140,100	$238	$1.64	$1.16 - $2.26
Q2 2024	122,200	$167	$2.02	$1.25 - $3.85
Q1 2024	144,400	$542	$5.86	$3.46 - $9.99
Q4 2023	151,800	$1,489	$8.18	$5.74 - $10.65
Q3 2023	174,400	$1,456	$11.43	$8.16 - $14.55
Q2 2023	194,800	$2,591	$12.15	$9.85 - $14.30
Q1 2023	164,600	$1,906	$9.94	$7.77 - $12.54
Q4 2022	187,000	$1,530	$8.62	$5.46 - $12.37
Q3 2022	983,000	$5,706	$5.74	$3.89 - $14.20
Q2 2022	3,580,600	$15,826	$6.08	$3.85 - $10.48
Q1 2022	1,088,300	$9,904	$11.51	$8.26 - $21.01
Q4 2021	382,400	$7,824	$24.13	$18.26 - $31.10
Q3 2021	560,800	$14,328	$29.63	$24.31 - $35.58
Q2 2021	507,300	$17,740	$29.09	$20.22 - $37.42
Q1 2021	231,800	$7,721	$35.00	$24.47 - $53.69
Q4 2019	16,600	$85	$5.08	$4.37 - $5.69
Q3 2019	38,600	$199	$5.59	$4.96 - $6.21
Q2 2019	225,600	$1,365	$7.01	$5.80 - $7.50
Q4 2017	30,700	$81	$3.50	$2.51 - $5.58
Q3 2017	18,700	$98	$4.30	$3.08 - $5.70
Q4 2014	72,600	$569	$6.40	$4.52 - $8.10