PRAXIS PRECISION MEDICINES I

CUSIP: 74006W108 Class: Common Stock

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q3 2023
Shares 56,900 Value ($000) $97 Avg Close — Range —
Q2 2023
Shares 12,100 Value ($000) $14 Avg Close — Range —
Q1 2023
Shares 52,800 Value ($000) $43 Avg Close — Range —
Q4 2022
Shares 278,772 Value ($000) $663 Avg Close — Range —
Q3 2022
Shares 441,987 Value ($000) $1,003 Avg Close — Range —
Q2 2022
Shares 403,632 Value ($000) $989 Avg Close — Range —
Q1 2022
Shares 114,263 Value ($000) $1,167 Avg Close — Range —
Q4 2021
Shares 152,161 Value ($000) $2,998 Avg Close — Range —
Q3 2021
Shares 126,608 Value ($000) $2,341 Avg Close — Range —
Q2 2021
Shares 184,292 Value ($000) $3,369 Avg Close — Range —