PRIME MEDICINE INC

Ticker: PRME CUSIP: 74168J101 Class: Common Stock

D. E. Shaw & Co., Inc.'s Holding History (CIK: 0001009207)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 1,551,369 Value ($000) $5,383 Avg Close $4.45 Range $3.17 - $6.94

Q3 2025

Shares 2,215,852 Value ($000) $12,276 Avg Close $4.06 Range $2.28 - $5.63

Q3 2024

Shares 139,451 Value ($000) $540 Avg Close $4.63 Range $3.39 - $6.75

Q2 2024

Shares 45,435 Value ($000) $234 Avg Close $6.06 Range $4.11 - $8.27

Q1 2024

Shares 26,668 Value ($000) $187 Avg Close $7.58 Range $6.22 - $9.77

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	1,551,369	$5,383	$4.45	$3.17 - $6.94
Q3 2025	2,215,852	$12,276	$4.06	$2.28 - $5.63
Q3 2024	139,451	$540	$4.63	$3.39 - $6.75
Q2 2024	45,435	$234	$6.06	$4.11 - $8.27
Q1 2024	26,668	$187	$7.58	$6.22 - $9.77