PRIME MEDICINE INC

Ticker: PRME CUSIP: 74168J101 Class: Common Stock

ADAGE CAPITAL PARTNERS GP, L.L.C.'s Holding History (CIK: 0001165408)

Note: Option positions (PUT/CALL) are excluded.

Q3 2025

Shares 771,361 Value ($000) $4,273 Avg Close $4.06 Range $2.28 - $5.63

Period	Shares	Value ($000)	Average Close	Price Range
Q3 2025	771,361	$4,273	$4.06	$2.28 - $5.63