PRIME MEDICINE INC

Ticker: PRME CUSIP: 74168J101 Class: Common Stock

JANUS HENDERSON GROUP PLC's Holding History (CIK: 0001274173)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 60,900 Value ($000) $210 Avg Close $4.45 Range $3.17 - $6.94

Q3 2023

Shares 120,946 Value ($000) $1,152 Avg Close $12.99 Range $9.25 - $15.75

Q2 2023

Shares 564,854 Value ($000) $8,269 Avg Close $13.96 Range $11.25 - $17.20

Q1 2023

Shares 14,091 Value ($000) $173 Avg Close $16.29 Range $11.07 - $21.48

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	60,900	$210	$4.45	$3.17 - $6.94
Q3 2023	120,946	$1,152	$12.99	$9.25 - $15.75
Q2 2023	564,854	$8,269	$13.96	$11.25 - $17.20
Q1 2023	14,091	$173	$16.29	$11.07 - $21.48