PROMETHEUS BIOSCIENCES INC

CUSIP: 74349U108 Class: Common Stock

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q1 2023
Shares 54,988 Value ($000) $5,901 Avg Close — Range —
Q4 2022
Shares 162,834 Value ($000) $17,912 Avg Close — Range —
Q3 2022
Shares 194,614 Value ($000) $11,484 Avg Close — Range —
Q2 2022
Shares 49,758 Value ($000) $1,405 Avg Close — Range —