PROTALIX BIOTHERAPEUTICS INC

Ticker: PLX CUSIP: 74365A309 Class: Common Stock

MANUFACTURERS LIFE INSURANCE COMPANY, THE's Holding History (CIK: 0000928047)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 18,498 Value ($000) $33 Avg Close $2.04 Range $1.60 - $2.66

Q3 2025

Shares 24,054 Value ($000) $53 Avg Close $1.63 Range $1.36 - $2.26

Q4 2023

Shares 10,514 Value ($000) $19 Avg Close $1.56 Range $1.21 - $1.90

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	18,498	$33	$2.04	$1.60 - $2.66
Q3 2025	24,054	$53	$1.63	$1.36 - $2.26
Q4 2023	10,514	$19	$1.56	$1.21 - $1.90