PROTEOSTASIS THERAPEUTICS IN

CUSIP: 74373B109 Class: COM

FMR LLC's Holding History (CIK: 0000315066)

Note: Option positions (PUT/CALL) are excluded.

Q1 2019
Shares 4,823 Value ($000) $6 Avg Close — Range —
Q4 2018
Shares 4,823 Value ($000) $16 Avg Close — Range —
Q3 2018
Shares 4,823 Value ($000) $12 Avg Close — Range —
Q1 2018
Shares 800,967 Value ($000) $3,805 Avg Close — Range —
Q4 2017
Shares 857,500 Value ($000) $4,999 Avg Close — Range —
Q3 2017
Shares 858,340 Value ($000) $1,803 Avg Close — Range —
Q2 2017
Shares 2,944,915 Value ($000) $13,782 Avg Close — Range —
Q1 2017
Shares 2,878,804 Value ($000) $22,513 Avg Close — Range —
Q4 2016
Shares 2,206,868 Value ($000) $27,056 Avg Close — Range —
Q3 2016
Shares 2,314,468 Value ($000) $36,083 Avg Close — Range —
Q2 2016
Shares 1,877,812 Value ($000) $22,778 Avg Close — Range —
Q1 2016
Shares 1,877,812 Value ($000) $18,102 Avg Close — Range —