PROTEOSTASIS THERAPEUTICS IN

CUSIP: 74373B109 Class: COM

MANUFACTURERS LIFE INSURANCE COMPANY, THE's Holding History (CIK: 0000928047)

Note: Option positions (PUT/CALL) are excluded.

Q1 2019
Shares 10,423 Value ($000) $13 Avg Close — Range —
Q4 2018
Shares 10,650 Value ($000) $35 Avg Close — Range —
Q2 2018
Shares 1,327 Value ($000) $4 Avg Close — Range —
Q1 2018
Shares 1,327 Value ($000) $6 Avg Close — Range —
Q2 2017
Shares 722 Value ($000) $3 Avg Close — Range —
Q1 2017
Shares 622 Value ($000) $5 Avg Close — Range —
Q4 2016
Shares 622 Value ($000) $8 Avg Close — Range —
Q3 2016
Shares 2,401 Value ($000) $37 Avg Close — Range —
Q2 2016
Shares 93 Value ($000) $1 Avg Close — Range —