PROTEOSTASIS THERAPEUTICS IN

CUSIP: 74373B109 Class: COM

D. E. Shaw & Co., Inc.'s Holding History (CIK: 0001009207)

Note: Option positions (PUT/CALL) are excluded.

Q2 2019
Shares 35,288 Value ($000) $34 Avg Close — Range —
Q1 2019
Shares 42,060 Value ($000) $53 Avg Close — Range —
Q4 2018
Shares 120,065 Value ($000) $389 Avg Close — Range —