PROTEOSTASIS THERAPEUTICS IN

CUSIP: 74373B109 Class: COM

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q2 2020
Shares 186,949 Value ($000) $256 Avg Close — Range —
Q1 2020
Shares 160,422 Value ($000) $183 Avg Close — Range —
Q3 2019
Shares 135,373 Value ($000) $114 Avg Close — Range —
Q2 2019
Shares 234,518 Value ($000) $229 Avg Close — Range —
Q4 2018
Shares 118,361 Value ($000) $383 Avg Close — Range —
Q3 2018
Shares 64,812 Value ($000) $156 Avg Close — Range —
Q1 2018
Shares 62,223 Value ($000) $296 Avg Close — Range —
Q3 2017
Shares 16,962 Value ($000) $36 Avg Close — Range —
Q3 2016
Shares 32,411 Value ($000) $505 Avg Close — Range —