PROTEOSTASIS THERAPEUTICS IN

CUSIP: 74373B109 Class: COM

MARSHALL WACE, LLP's Holding History (CIK: 0001318757)

Note: Option positions (PUT/CALL) are excluded.

Q4 2016
Shares 442,836 Value ($000) $5,429 Avg Close — Range —
Q3 2016
Shares 334,970 Value ($000) $5,222 Avg Close — Range —