PROTEOSTASIS THERAPEUTICS IN

CUSIP: 74373B109 Class: COM

EVENTIDE ASSET MANAGEMENT, LLC's Holding History (CIK: 0001442891)

Note: Option positions (PUT/CALL) are excluded.

Q1 2017

Shares 108,000 Value ($000) $845 Avg Close — Range —

Q4 2016

Shares 220,000 Value ($000) $2,697 Avg Close — Range —

Q3 2016

Shares 220,000 Value ($000) $3,430 Avg Close — Range —

Q2 2016

Shares 200,000 Value ($000) $2,426 Avg Close — Range —

Q1 2016

Shares 200,000 Value ($000) $1,928 Avg Close — Range —

Period	Shares	Value ($000)	Average Close	Price Range
Q1 2017	108,000	$845	—	—
Q4 2016	220,000	$2,697	—	—
Q3 2016	220,000	$3,430	—	—
Q2 2016	200,000	$2,426	—	—
Q1 2016	200,000	$1,928	—	—