PROTEOSTASIS THERAPEUTICS IN

CUSIP: 74373B109 Class: COM

TWO SIGMA ADVISERS, LP's Holding History (CIK: 0001478735)

Note: Option positions (PUT/CALL) are excluded.

Q3 2020
Shares 162,500 Value ($000) $179 Avg Close — Range —
Q2 2020
Shares 186,600 Value ($000) $256 Avg Close — Range —
Q1 2020
Shares 168,900 Value ($000) $193 Avg Close — Range —
Q4 2019
Shares 151,700 Value ($000) $346 Avg Close — Range —
Q3 2019
Shares 64,900 Value ($000) $55 Avg Close — Range —
Q2 2019
Shares 48,100 Value ($000) $47 Avg Close — Range —
Q1 2019
Shares 18,900 Value ($000) $24 Avg Close — Range —
Q4 2018
Shares 36,900 Value ($000) $120 Avg Close — Range —
Q3 2018
Shares 38,000 Value ($000) $92 Avg Close — Range —
Q2 2018
Shares 50,400 Value ($000) $141 Avg Close — Range —