PROTEOSTASIS THERAPEUTICS IN

CUSIP: 74373B109 Class: COM

JGP Global Gestao de Recursos Ltda.'s Holding History (CIK: 0001536562)

Note: Option positions (PUT/CALL) are excluded.

Q1 2019
Shares 21,871 Value ($000) $28 Avg Close — Range —
Q4 2018
Shares 19,790 Value ($000) $64 Avg Close — Range —