REGENERON PHARMACEUTICALS

Ticker: REGN CUSIP: 75886F107 Class: COM

MANUFACTURERS LIFE INSURANCE COMPANY, THE's Holding History (CIK: 0000928047)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 421,229 Value ($000) $325,260 Avg Close $678.68 Range $540.32 - $792.77

Q3 2025

Shares 381,015 Value ($000) $214,233 Avg Close $564.28 Range $519.56 - $609.69

Q2 2025

Shares 379,537 Value ($000) $199,255 Avg Close $556.12 Range $475.17 - $638.52

Q1 2025

Shares 398,236 Value ($000) $252,574 Avg Close $684.44 Range $615.89 - $745.12

Q4 2024

Shares 356,410 Value ($000) $253,876 Avg Close $834.60 Range $689.18 - $1055.74

Q3 2024

Shares 338,044 Value ($000) $355,365 Avg Close $1106.73 Range $1002.85 - $1204.52

Q2 2024

Shares 340,566 Value ($000) $357,945 Avg Close $964.05 Range $870.40 - $1075.21

Q1 2024

Shares 338,296 Value ($000) $325,606 Avg Close $945.64 Range $866.58 - $992.82

Q4 2023

Shares 339,660 Value ($000) $298,320 Avg Close $818.96 Range $764.95 - $894.90

Q3 2023

Shares 365,974 Value ($000) $301,182 Avg Close $781.58 Range $684.72 - $842.83

Q2 2023

Shares 364,500 Value ($000) $261,908 Avg Close $766.75 Range $681.03 - $832.93

Q1 2023

Shares 350,865 Value ($000) $288,295 Avg Close $750.05 Range $664.32 - $830.39

Q4 2022

Shares 345,411 Value ($000) $249,196 Avg Close $733.79 Range $690.81 - $774.70

Q3 2022

Shares 264,879 Value ($000) $182,659 Avg Close $625.92 Range $560.71 - $750.51

Q2 2022

Shares 256,500 Value ($000) $151,986 Avg Close $646.43 Range $535.04 - $743.30

Q1 2022

Shares 250,743 Value ($000) $174,832 Avg Close $629.16 Range $589.59 - $706.29

Q4 2021

Shares 201,085 Value ($000) $127,956 Avg Close $611.44 Range $536.21 - $670.14

Q3 2021

Shares 195,116 Value ($000) $118,080 Avg Close $617.39 Range $551.89 - $682.83

Q2 2021

Shares 102,019 Value ($000) $56,982 Avg Close $503.83 Range $466.78 - $566.85

Q1 2021

Shares 103,725 Value ($000) $49,077 Avg Close $484.19 Range $438.57 - $555.83

Q4 2020

Shares 96,508 Value ($000) $46,624 Avg Close $536.82 Range $468.18 - $616.55

Q3 2020

Shares 98,450 Value ($000) $55,110 Avg Close $602.99 Range $537.02 - $660.97

Q2 2020

Shares 107,979 Value ($000) $65,961 Avg Close $564.49 Range $473.82 - $642.77

Q1 2020

Shares 87,584 Value ($000) $42,766 Avg Close $410.21 Range $326.32 - $515.14

Q4 2019

Shares 75,698 Value ($000) $28,424 Avg Close $334.59 Range $270.76 - $380.14

Q3 2019

Shares 77,808 Value ($000) $21,277 Avg Close $294.28 Range $269.87 - $318.99

Q2 2019

Shares 74,866 Value ($000) $23,433 Avg Close $331.08 Range $293.64 - $413.60

Q1 2019

Shares 80,926 Value ($000) $33,230 Avg Close $409.51 Range $363.99 - $439.56

Q4 2018

Shares 78,377 Value ($000) $29,275 Avg Close $364.00 Range $325.77 - $407.74

Q3 2018

Shares 80,118 Value ($000) $32,371 Avg Close $378.49 Range $340.69 - $414.19

Q2 2018

Shares 83,671 Value ($000) $28,865 Avg Close $311.03 Range $280.34 - $347.31

Q1 2018

Shares 76,261 Value ($000) $26,262 Avg Close $345.90 Range $311.80 - $394.59

Q4 2017

Shares 80,853 Value ($000) $30,397 Avg Close $402.77 Range $351.19 - $474.37

Q3 2017

Shares 86,285 Value ($000) $38,580 Avg Close $473.21 Range $424.12 - $523.22

Q2 2017

Shares 84,977 Value ($000) $41,735 Avg Close $435.19 Range $358.01 - $540.55

Q1 2017

Shares 83,940 Value ($000) $32,529 Avg Close $368.62 Range $338.21 - $399.00

Q4 2016

Shares 79,733 Value ($000) $29,269 Avg Close $378.17 Range $323.56 - $450.46

Q3 2016

Shares 76,041 Value ($000) $30,570 Avg Close $398.92 Range $346.51 - $441.54

Q2 2016

Shares 75,443 Value ($000) $26,347 Avg Close $383.00 Range $327.27 - $431.54

Q1 2016

Shares 72,849 Value ($000) $26,201 Avg Close $409.79 Range $347.04 - $529.97

Q4 2015

Shares 79,493 Value ($000) $43,154 Avg Close $538.82 Range $445.63 - $589.32

Q3 2015

Shares 81,078 Value ($000) $37,713 Avg Close $534.07 Range $433.12 - $602.59

Q2 2015

Shares 76,812 Value ($000) $39,185 Avg Close $485.93 Range $431.08 - $541.00

Q1 2015

Shares 76,330 Value ($000) $34,461 Avg Close $421.46 Range $390.83 - $492.77

Q4 2014

Shares 78,822 Value ($000) $32,335 Avg Close $391.09 Range $318.29 - $435.23

Q3 2014

Shares 75,854 Value ($000) $27,347 Avg Close $333.32 Range $283.49 - $367.27

Q2 2014

Shares 82,357 Value ($000) $23,263 Avg Close $294.74 Range $268.01 - $318.24

Q1 2014

Shares 78,779 Value ($000) $23,656 Avg Close $306.39 Range $261.52 - $350.55

Q4 2013

Shares 77,052 Value ($000) $21,208 Avg Close $286.03 Range $256.27 - $317.74

Q3 2013

Shares 85,078 Value ($000) $26,617 Avg Close $261.58 Range $224.53 - $318.07

Q2 2013

Shares 80,485 Value ($000) $18,099 Avg Close $231.58 Range $176.14 - $282.42

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	421,229	$325,260	$678.68	$540.32 - $792.77
Q3 2025	381,015	$214,233	$564.28	$519.56 - $609.69
Q2 2025	379,537	$199,255	$556.12	$475.17 - $638.52
Q1 2025	398,236	$252,574	$684.44	$615.89 - $745.12
Q4 2024	356,410	$253,876	$834.60	$689.18 - $1055.74
Q3 2024	338,044	$355,365	$1106.73	$1002.85 - $1204.52
Q2 2024	340,566	$357,945	$964.05	$870.40 - $1075.21
Q1 2024	338,296	$325,606	$945.64	$866.58 - $992.82
Q4 2023	339,660	$298,320	$818.96	$764.95 - $894.90
Q3 2023	365,974	$301,182	$781.58	$684.72 - $842.83
Q2 2023	364,500	$261,908	$766.75	$681.03 - $832.93
Q1 2023	350,865	$288,295	$750.05	$664.32 - $830.39
Q4 2022	345,411	$249,196	$733.79	$690.81 - $774.70
Q3 2022	264,879	$182,659	$625.92	$560.71 - $750.51
Q2 2022	256,500	$151,986	$646.43	$535.04 - $743.30
Q1 2022	250,743	$174,832	$629.16	$589.59 - $706.29
Q4 2021	201,085	$127,956	$611.44	$536.21 - $670.14
Q3 2021	195,116	$118,080	$617.39	$551.89 - $682.83
Q2 2021	102,019	$56,982	$503.83	$466.78 - $566.85
Q1 2021	103,725	$49,077	$484.19	$438.57 - $555.83
Q4 2020	96,508	$46,624	$536.82	$468.18 - $616.55
Q3 2020	98,450	$55,110	$602.99	$537.02 - $660.97
Q2 2020	107,979	$65,961	$564.49	$473.82 - $642.77
Q1 2020	87,584	$42,766	$410.21	$326.32 - $515.14
Q4 2019	75,698	$28,424	$334.59	$270.76 - $380.14
Q3 2019	77,808	$21,277	$294.28	$269.87 - $318.99
Q2 2019	74,866	$23,433	$331.08	$293.64 - $413.60
Q1 2019	80,926	$33,230	$409.51	$363.99 - $439.56
Q4 2018	78,377	$29,275	$364.00	$325.77 - $407.74
Q3 2018	80,118	$32,371	$378.49	$340.69 - $414.19
Q2 2018	83,671	$28,865	$311.03	$280.34 - $347.31
Q1 2018	76,261	$26,262	$345.90	$311.80 - $394.59
Q4 2017	80,853	$30,397	$402.77	$351.19 - $474.37
Q3 2017	86,285	$38,580	$473.21	$424.12 - $523.22
Q2 2017	84,977	$41,735	$435.19	$358.01 - $540.55
Q1 2017	83,940	$32,529	$368.62	$338.21 - $399.00
Q4 2016	79,733	$29,269	$378.17	$323.56 - $450.46
Q3 2016	76,041	$30,570	$398.92	$346.51 - $441.54
Q2 2016	75,443	$26,347	$383.00	$327.27 - $431.54
Q1 2016	72,849	$26,201	$409.79	$347.04 - $529.97
Q4 2015	79,493	$43,154	$538.82	$445.63 - $589.32
Q3 2015	81,078	$37,713	$534.07	$433.12 - $602.59
Q2 2015	76,812	$39,185	$485.93	$431.08 - $541.00
Q1 2015	76,330	$34,461	$421.46	$390.83 - $492.77
Q4 2014	78,822	$32,335	$391.09	$318.29 - $435.23
Q3 2014	75,854	$27,347	$333.32	$283.49 - $367.27
Q2 2014	82,357	$23,263	$294.74	$268.01 - $318.24
Q1 2014	78,779	$23,656	$306.39	$261.52 - $350.55
Q4 2013	77,052	$21,208	$286.03	$256.27 - $317.74
Q3 2013	85,078	$26,617	$261.58	$224.53 - $318.07
Q2 2013	80,485	$18,099	$231.58	$176.14 - $282.42