REGENERON PHARMACEUTICALS

Ticker: REGN CUSIP: 75886F107 Class: COM

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 281,151 Value ($000) $217,012 Avg Close $678.68 Range $540.32 - $792.77

Q3 2025

Shares 469,903 Value ($000) $264,212 Avg Close $564.28 Range $519.56 - $609.69

Q2 2025

Shares 499,828 Value ($000) $262,410 Avg Close $556.12 Range $475.17 - $638.52

Q1 2025

Shares 372,071 Value ($000) $235,979 Avg Close $684.44 Range $615.89 - $745.12

Q4 2024

Shares 34,543 Value ($000) $24,606 Avg Close $834.60 Range $689.18 - $1055.74

Q3 2024

Shares 22,389 Value ($000) $23,536 Avg Close $1106.73 Range $1002.85 - $1204.52

Q1 2024

Shares 4,781 Value ($000) $4,602 Avg Close $945.64 Range $866.58 - $992.82

Q4 2023

Shares 65,218 Value ($000) $57,280 Avg Close $818.96 Range $764.95 - $894.90

Q3 2023

Shares 88,715 Value ($000) $73,009 Avg Close $781.58 Range $684.72 - $842.83

Q2 2023

Shares 123,626 Value ($000) $88,830 Avg Close $766.75 Range $681.03 - $832.93

Q1 2023

Shares 189,295 Value ($000) $155,538 Avg Close $750.05 Range $664.32 - $830.39

Q4 2022

Shares 32,158 Value ($000) $23,202 Avg Close $733.79 Range $690.81 - $774.70

Q1 2022

Shares 207,430 Value ($000) $144,873 Avg Close $629.16 Range $589.59 - $706.29

Q4 2021

Shares 323,417 Value ($000) $204,244 Avg Close $611.44 Range $536.21 - $670.14

Q3 2021

Shares 5,068 Value ($000) $3,067 Avg Close $617.39 Range $551.89 - $682.83

Q4 2020

Shares 6,492 Value ($000) $3,136 Avg Close $536.82 Range $468.18 - $616.55

Q1 2020

Shares 51,959 Value ($000) $25,371 Avg Close $410.21 Range $326.32 - $515.14

Q3 2019

Shares 127,116 Value ($000) $35,262 Avg Close $294.28 Range $269.87 - $318.99

Q1 2019

Shares 23,316 Value ($000) $9,574 Avg Close $409.51 Range $363.99 - $439.56

Q4 2018

Shares 35,498 Value ($000) $13,259 Avg Close $364.00 Range $325.77 - $407.74

Q3 2018

Shares 111,072 Value ($000) $44,878 Avg Close $378.49 Range $340.69 - $414.19

Q1 2018

Shares 455,919 Value ($000) $157,000 Avg Close $345.90 Range $311.80 - $394.59

Q4 2017

Shares 343,772 Value ($000) $129,245 Avg Close $402.77 Range $351.19 - $474.37

Q1 2017

Shares 34,212 Value ($000) $13,257 Avg Close $368.62 Range $338.21 - $399.00

Q4 2016

Shares 68,606 Value ($000) $25,185 Avg Close $378.17 Range $323.56 - $450.46

Q3 2016

Shares 3,575 Value ($000) $1,437 Avg Close $398.92 Range $346.51 - $441.54

Q2 2016

Shares 260,963 Value ($000) $91,136 Avg Close $383.00 Range $327.27 - $431.54

Q1 2016

Shares 259,793 Value ($000) $93,640 Avg Close $409.79 Range $347.04 - $529.97

Q4 2015

Shares 286,430 Value ($000) $155,494 Avg Close $538.82 Range $445.63 - $589.32

Q3 2015

Shares 216,830 Value ($000) $100,856 Avg Close $534.07 Range $433.12 - $602.59

Q1 2015

Shares 696 Value ($000) $314 Avg Close $421.46 Range $390.83 - $492.77

Q3 2014

Shares 75,270 Value ($000) $27,136 Avg Close $333.32 Range $283.49 - $367.27

Q1 2014

Shares 156,377 Value ($000) $46,956 Avg Close $306.39 Range $261.52 - $350.55

Q2 2013

Shares 215,680 Value ($000) $48,502 Avg Close $231.58 Range $176.14 - $282.42

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	281,151	$217,012	$678.68	$540.32 - $792.77
Q3 2025	469,903	$264,212	$564.28	$519.56 - $609.69
Q2 2025	499,828	$262,410	$556.12	$475.17 - $638.52
Q1 2025	372,071	$235,979	$684.44	$615.89 - $745.12
Q4 2024	34,543	$24,606	$834.60	$689.18 - $1055.74
Q3 2024	22,389	$23,536	$1106.73	$1002.85 - $1204.52
Q1 2024	4,781	$4,602	$945.64	$866.58 - $992.82
Q4 2023	65,218	$57,280	$818.96	$764.95 - $894.90
Q3 2023	88,715	$73,009	$781.58	$684.72 - $842.83
Q2 2023	123,626	$88,830	$766.75	$681.03 - $832.93
Q1 2023	189,295	$155,538	$750.05	$664.32 - $830.39
Q4 2022	32,158	$23,202	$733.79	$690.81 - $774.70
Q1 2022	207,430	$144,873	$629.16	$589.59 - $706.29
Q4 2021	323,417	$204,244	$611.44	$536.21 - $670.14
Q3 2021	5,068	$3,067	$617.39	$551.89 - $682.83
Q4 2020	6,492	$3,136	$536.82	$468.18 - $616.55
Q1 2020	51,959	$25,371	$410.21	$326.32 - $515.14
Q3 2019	127,116	$35,262	$294.28	$269.87 - $318.99
Q1 2019	23,316	$9,574	$409.51	$363.99 - $439.56
Q4 2018	35,498	$13,259	$364.00	$325.77 - $407.74
Q3 2018	111,072	$44,878	$378.49	$340.69 - $414.19
Q1 2018	455,919	$157,000	$345.90	$311.80 - $394.59
Q4 2017	343,772	$129,245	$402.77	$351.19 - $474.37
Q1 2017	34,212	$13,257	$368.62	$338.21 - $399.00
Q4 2016	68,606	$25,185	$378.17	$323.56 - $450.46
Q3 2016	3,575	$1,437	$398.92	$346.51 - $441.54
Q2 2016	260,963	$91,136	$383.00	$327.27 - $431.54
Q1 2016	259,793	$93,640	$409.79	$347.04 - $529.97
Q4 2015	286,430	$155,494	$538.82	$445.63 - $589.32
Q3 2015	216,830	$100,856	$534.07	$433.12 - $602.59
Q1 2015	696	$314	$421.46	$390.83 - $492.77
Q3 2014	75,270	$27,136	$333.32	$283.49 - $367.27
Q1 2014	156,377	$46,956	$306.39	$261.52 - $350.55
Q2 2013	215,680	$48,502	$231.58	$176.14 - $282.42