REGENERON PHARMACEUTICALS

Ticker: REGN CUSIP: 75886F107 Class: COM

JANUS HENDERSON GROUP PLC's Holding History (CIK: 0001274173)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 205,672 Value ($000) $158,791 Avg Close $678.68 Range $540.32 - $792.77

Q3 2025

Shares 73,743 Value ($000) $41,480 Avg Close $564.28 Range $519.56 - $609.69

Q2 2025

Shares 13,088 Value ($000) $6,867 Avg Close $556.12 Range $475.17 - $638.52

Q1 2025

Shares 13,553 Value ($000) $8,644 Avg Close $684.44 Range $615.89 - $745.12

Q4 2024

Shares 13,473 Value ($000) $9,599 Avg Close $834.60 Range $689.18 - $1055.74

Q3 2024

Shares 98,134 Value ($000) $103,180 Avg Close $1106.73 Range $1002.85 - $1204.52

Q2 2024

Shares 100,424 Value ($000) $105,559 Avg Close $964.05 Range $870.40 - $1075.21

Q1 2024

Shares 103,992 Value ($000) $100,085 Avg Close $945.64 Range $866.58 - $992.82

Q4 2023

Shares 112,829 Value ($000) $99,099 Avg Close $818.96 Range $764.95 - $894.90

Q3 2023

Shares 122,413 Value ($000) $100,739 Avg Close $781.58 Range $684.72 - $842.83

Q2 2023

Shares 87,293 Value ($000) $62,728 Avg Close $766.75 Range $681.03 - $832.93

Q1 2023

Shares 197,071 Value ($000) $161,923 Avg Close $750.05 Range $664.32 - $830.39

Q4 2022

Shares 247,022 Value ($000) $178,227 Avg Close $733.79 Range $690.81 - $774.70

Q3 2022

Shares 285,273 Value ($000) $196,531 Avg Close $625.92 Range $560.71 - $750.51

Q2 2022

Shares 155,519 Value ($000) $91,934 Avg Close $646.43 Range $535.04 - $743.30

Q1 2022

Shares 168,702 Value ($000) $117,830 Avg Close $629.16 Range $589.59 - $706.29

Q4 2021

Shares 178,978 Value ($000) $113,032 Avg Close $611.44 Range $536.21 - $670.14

Q3 2021

Shares 197,646 Value ($000) $119,606 Avg Close $617.39 Range $551.89 - $682.83

Q2 2021

Shares 207,946 Value ($000) $116,151 Avg Close $503.83 Range $466.78 - $566.85

Q1 2021

Shares 234,327 Value ($000) $110,873 Avg Close $484.19 Range $438.57 - $555.83

Q4 2020

Shares 381,823 Value ($000) $184,457 Avg Close $536.82 Range $468.18 - $616.55

Q3 2020

Shares 341,587 Value ($000) $191,208 Avg Close $602.99 Range $537.02 - $660.97

Q2 2020

Shares 295,015 Value ($000) $183,975 Avg Close $564.49 Range $473.82 - $642.77

Q1 2020

Shares 37,931 Value ($000) $18,522 Avg Close $410.21 Range $326.32 - $515.14

Q4 2019

Shares 28,568 Value ($000) $10,728 Avg Close $334.59 Range $270.76 - $380.14

Q3 2019

Shares 231,734 Value ($000) $64,283 Avg Close $294.28 Range $269.87 - $318.99

Q2 2019

Shares 298,132 Value ($000) $93,315 Avg Close $331.08 Range $293.64 - $413.60

Q1 2019

Shares 430,152 Value ($000) $176,629 Avg Close $409.51 Range $363.99 - $439.56

Q4 2018

Shares 936,150 Value ($000) $349,655 Avg Close $364.00 Range $325.77 - $407.74

Q3 2018

Shares 1,542,041 Value ($000) $623,047 Avg Close $378.49 Range $340.69 - $414.19

Q2 2018

Shares 1,802,740 Value ($000) $621,927 Avg Close $311.03 Range $280.34 - $347.31

Q1 2018

Shares 1,599,434 Value ($000) $550,528 Avg Close $345.90 Range $311.80 - $394.59

Q4 2017

Shares 1,673,840 Value ($000) $629,299 Avg Close $402.77 Range $351.19 - $474.37

Q3 2017

Shares 1,545,330 Value ($000) $690,947 Avg Close $473.21 Range $424.12 - $523.22

Q2 2017

Shares 1,562,970 Value ($000) $767,637 Avg Close $435.19 Range $358.01 - $540.55

Q1 2017

Shares 10,022 Value ($000) $3,883 Avg Close $368.62 Range $338.21 - $399.00

Q4 2016

Shares 9,822 Value ($000) $3,607 Avg Close $378.17 Range $323.56 - $450.46

Q3 2016

Shares 9,420 Value ($000) $3,787 Avg Close $398.92 Range $346.51 - $441.54

Q2 2016

Shares 9,420 Value ($000) $3,290 Avg Close $383.00 Range $327.27 - $431.54

Q1 2016

Shares 9,420 Value ($000) $3,396 Avg Close $409.79 Range $347.04 - $529.97

Q4 2015

Shares 28,299 Value ($000) $15,360 Avg Close $538.82 Range $445.63 - $589.32

Q3 2015

Shares 24,170 Value ($000) $11,226 Avg Close $534.07 Range $433.12 - $602.59

Q2 2015

Shares 9,812 Value ($000) $5,007 Avg Close $485.93 Range $431.08 - $541.00

Q1 2015

Shares 11,206 Value ($000) $5,059 Avg Close $421.46 Range $390.83 - $492.77

Q4 2014

Shares 11,206 Value ($000) $4,596 Avg Close $391.09 Range $318.29 - $435.23

Q3 2014

Shares 11,206 Value ($000) $4,040 Avg Close $333.32 Range $283.49 - $367.27

Q2 2014

Shares 11,206 Value ($000) $3,165 Avg Close $294.74 Range $268.01 - $318.24

Q1 2014

Shares 11,206 Value ($000) $3,365 Avg Close $306.39 Range $261.52 - $350.55

Q4 2013

Shares 9,056 Value ($000) $2,492 Avg Close $286.03 Range $256.27 - $317.74

Q3 2013

Shares 9,056 Value ($000) $2,833 Avg Close $261.58 Range $224.53 - $318.07

Q2 2013

Shares 8,248 Value ($000) $1,899 Avg Close $231.58 Range $176.14 - $282.42

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	205,672	$158,791	$678.68	$540.32 - $792.77
Q3 2025	73,743	$41,480	$564.28	$519.56 - $609.69
Q2 2025	13,088	$6,867	$556.12	$475.17 - $638.52
Q1 2025	13,553	$8,644	$684.44	$615.89 - $745.12
Q4 2024	13,473	$9,599	$834.60	$689.18 - $1055.74
Q3 2024	98,134	$103,180	$1106.73	$1002.85 - $1204.52
Q2 2024	100,424	$105,559	$964.05	$870.40 - $1075.21
Q1 2024	103,992	$100,085	$945.64	$866.58 - $992.82
Q4 2023	112,829	$99,099	$818.96	$764.95 - $894.90
Q3 2023	122,413	$100,739	$781.58	$684.72 - $842.83
Q2 2023	87,293	$62,728	$766.75	$681.03 - $832.93
Q1 2023	197,071	$161,923	$750.05	$664.32 - $830.39
Q4 2022	247,022	$178,227	$733.79	$690.81 - $774.70
Q3 2022	285,273	$196,531	$625.92	$560.71 - $750.51
Q2 2022	155,519	$91,934	$646.43	$535.04 - $743.30
Q1 2022	168,702	$117,830	$629.16	$589.59 - $706.29
Q4 2021	178,978	$113,032	$611.44	$536.21 - $670.14
Q3 2021	197,646	$119,606	$617.39	$551.89 - $682.83
Q2 2021	207,946	$116,151	$503.83	$466.78 - $566.85
Q1 2021	234,327	$110,873	$484.19	$438.57 - $555.83
Q4 2020	381,823	$184,457	$536.82	$468.18 - $616.55
Q3 2020	341,587	$191,208	$602.99	$537.02 - $660.97
Q2 2020	295,015	$183,975	$564.49	$473.82 - $642.77
Q1 2020	37,931	$18,522	$410.21	$326.32 - $515.14
Q4 2019	28,568	$10,728	$334.59	$270.76 - $380.14
Q3 2019	231,734	$64,283	$294.28	$269.87 - $318.99
Q2 2019	298,132	$93,315	$331.08	$293.64 - $413.60
Q1 2019	430,152	$176,629	$409.51	$363.99 - $439.56
Q4 2018	936,150	$349,655	$364.00	$325.77 - $407.74
Q3 2018	1,542,041	$623,047	$378.49	$340.69 - $414.19
Q2 2018	1,802,740	$621,927	$311.03	$280.34 - $347.31
Q1 2018	1,599,434	$550,528	$345.90	$311.80 - $394.59
Q4 2017	1,673,840	$629,299	$402.77	$351.19 - $474.37
Q3 2017	1,545,330	$690,947	$473.21	$424.12 - $523.22
Q2 2017	1,562,970	$767,637	$435.19	$358.01 - $540.55
Q1 2017	10,022	$3,883	$368.62	$338.21 - $399.00
Q4 2016	9,822	$3,607	$378.17	$323.56 - $450.46
Q3 2016	9,420	$3,787	$398.92	$346.51 - $441.54
Q2 2016	9,420	$3,290	$383.00	$327.27 - $431.54
Q1 2016	9,420	$3,396	$409.79	$347.04 - $529.97
Q4 2015	28,299	$15,360	$538.82	$445.63 - $589.32
Q3 2015	24,170	$11,226	$534.07	$433.12 - $602.59
Q2 2015	9,812	$5,007	$485.93	$431.08 - $541.00
Q1 2015	11,206	$5,059	$421.46	$390.83 - $492.77
Q4 2014	11,206	$4,596	$391.09	$318.29 - $435.23
Q3 2014	11,206	$4,040	$333.32	$283.49 - $367.27
Q2 2014	11,206	$3,165	$294.74	$268.01 - $318.24
Q1 2014	11,206	$3,365	$306.39	$261.52 - $350.55
Q4 2013	9,056	$2,492	$286.03	$256.27 - $317.74
Q3 2013	9,056	$2,833	$261.58	$224.53 - $318.07
Q2 2013	8,248	$1,899	$231.58	$176.14 - $282.42