REGENERON PHARMACEUTICALS

Ticker: REGN CUSIP: 75886F107 Class: COM

TWO SIGMA ADVISERS, LP's Holding History (CIK: 0001478735)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 604,540 Value ($000) $466,626 Avg Close $678.68 Range $540.32 - $792.77

Q3 2025

Shares 926,200 Value ($000) $520,774 Avg Close $564.28 Range $519.56 - $609.69

Q2 2025

Shares 938,500 Value ($000) $492,713 Avg Close $556.12 Range $475.17 - $638.52

Q1 2025

Shares 553,800 Value ($000) $351,237 Avg Close $684.44 Range $615.89 - $745.12

Q3 2024

Shares 900 Value ($000) $946 Avg Close $1106.73 Range $1002.85 - $1204.52

Q2 2024

Shares 1,000 Value ($000) $1,051 Avg Close $964.05 Range $870.40 - $1075.21

Q4 2023

Shares 12,900 Value ($000) $11,330 Avg Close $818.96 Range $764.95 - $894.90

Q3 2023

Shares 242,900 Value ($000) $199,897 Avg Close $781.58 Range $684.72 - $842.83

Q2 2023

Shares 299,300 Value ($000) $215,059 Avg Close $766.75 Range $681.03 - $832.93

Q1 2023

Shares 209,800 Value ($000) $172,386 Avg Close $750.05 Range $664.32 - $830.39

Q4 2022

Shares 48,500 Value ($000) $34,992 Avg Close $733.79 Range $690.81 - $774.70

Q3 2022

Shares 115,900 Value ($000) $79,840 Avg Close $625.92 Range $560.71 - $750.51

Q2 2022

Shares 279,000 Value ($000) $164,925 Avg Close $646.43 Range $535.04 - $743.30

Q1 2022

Shares 489,200 Value ($000) $341,667 Avg Close $629.16 Range $589.59 - $706.29

Q4 2021

Shares 388,500 Value ($000) $245,346 Avg Close $611.44 Range $536.21 - $670.14

Q3 2020

Shares 52,799 Value ($000) $29,556 Avg Close $602.99 Range $537.02 - $660.97

Q2 2020

Shares 121,899 Value ($000) $76,022 Avg Close $564.49 Range $473.82 - $642.77

Q1 2020

Shares 49,600 Value ($000) $24,219 Avg Close $410.21 Range $326.32 - $515.14

Q4 2019

Shares 39,102 Value ($000) $14,682 Avg Close $334.59 Range $270.76 - $380.14

Q3 2019

Shares 283,301 Value ($000) $78,588 Avg Close $294.28 Range $269.87 - $318.99

Q2 2019

Shares 241,001 Value ($000) $75,433 Avg Close $331.08 Range $293.64 - $413.60

Q1 2019

Shares 291,601 Value ($000) $119,737 Avg Close $409.51 Range $363.99 - $439.56

Q4 2018

Shares 571,001 Value ($000) $213,269 Avg Close $364.00 Range $325.77 - $407.74

Q3 2018

Shares 616,801 Value ($000) $249,212 Avg Close $378.49 Range $340.69 - $414.19

Q2 2018

Shares 739,101 Value ($000) $254,982 Avg Close $311.03 Range $280.34 - $347.31

Q1 2018

Shares 700,301 Value ($000) $241,156 Avg Close $345.90 Range $311.80 - $394.59

Q4 2017

Shares 381,038 Value ($000) $143,255 Avg Close $402.77 Range $351.19 - $474.37

Q2 2017

Shares 2,588 Value ($000) $1,271 Avg Close $435.19 Range $358.01 - $540.55

Q1 2017

Shares 188,101 Value ($000) $72,891 Avg Close $368.62 Range $338.21 - $399.00

Q4 2016

Shares 207,780 Value ($000) $76,274 Avg Close $378.17 Range $323.56 - $450.46

Q3 2016

Shares 265,180 Value ($000) $106,608 Avg Close $398.92 Range $346.51 - $441.54

Q2 2016

Shares 387,180 Value ($000) $135,215 Avg Close $383.00 Range $327.27 - $431.54

Q1 2016

Shares 402,480 Value ($000) $145,070 Avg Close $409.79 Range $347.04 - $529.97

Q4 2015

Shares 253,667 Value ($000) $137,708 Avg Close $538.82 Range $445.63 - $589.32

Q3 2015

Shares 228,497 Value ($000) $106,743 Avg Close $534.07 Range $433.12 - $602.59

Q1 2015

Shares 480 Value ($000) $217 Avg Close $421.46 Range $390.83 - $492.77

Q3 2014

Shares 9,480 Value ($000) $3,418 Avg Close $333.32 Range $283.49 - $367.27

Q1 2014

Shares 6,280 Value ($000) $1,885 Avg Close $306.39 Range $261.52 - $350.55

Q4 2013

Shares 8,780 Value ($000) $2,417 Avg Close $286.03 Range $256.27 - $317.74

Q3 2013

Shares 106,180 Value ($000) $33,220 Avg Close $261.58 Range $224.53 - $318.07

Q2 2013

Shares 188,680 Value ($000) $42,430 Avg Close $231.58 Range $176.14 - $282.42

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	604,540	$466,626	$678.68	$540.32 - $792.77
Q3 2025	926,200	$520,774	$564.28	$519.56 - $609.69
Q2 2025	938,500	$492,713	$556.12	$475.17 - $638.52
Q1 2025	553,800	$351,237	$684.44	$615.89 - $745.12
Q3 2024	900	$946	$1106.73	$1002.85 - $1204.52
Q2 2024	1,000	$1,051	$964.05	$870.40 - $1075.21
Q4 2023	12,900	$11,330	$818.96	$764.95 - $894.90
Q3 2023	242,900	$199,897	$781.58	$684.72 - $842.83
Q2 2023	299,300	$215,059	$766.75	$681.03 - $832.93
Q1 2023	209,800	$172,386	$750.05	$664.32 - $830.39
Q4 2022	48,500	$34,992	$733.79	$690.81 - $774.70
Q3 2022	115,900	$79,840	$625.92	$560.71 - $750.51
Q2 2022	279,000	$164,925	$646.43	$535.04 - $743.30
Q1 2022	489,200	$341,667	$629.16	$589.59 - $706.29
Q4 2021	388,500	$245,346	$611.44	$536.21 - $670.14
Q3 2020	52,799	$29,556	$602.99	$537.02 - $660.97
Q2 2020	121,899	$76,022	$564.49	$473.82 - $642.77
Q1 2020	49,600	$24,219	$410.21	$326.32 - $515.14
Q4 2019	39,102	$14,682	$334.59	$270.76 - $380.14
Q3 2019	283,301	$78,588	$294.28	$269.87 - $318.99
Q2 2019	241,001	$75,433	$331.08	$293.64 - $413.60
Q1 2019	291,601	$119,737	$409.51	$363.99 - $439.56
Q4 2018	571,001	$213,269	$364.00	$325.77 - $407.74
Q3 2018	616,801	$249,212	$378.49	$340.69 - $414.19
Q2 2018	739,101	$254,982	$311.03	$280.34 - $347.31
Q1 2018	700,301	$241,156	$345.90	$311.80 - $394.59
Q4 2017	381,038	$143,255	$402.77	$351.19 - $474.37
Q2 2017	2,588	$1,271	$435.19	$358.01 - $540.55
Q1 2017	188,101	$72,891	$368.62	$338.21 - $399.00
Q4 2016	207,780	$76,274	$378.17	$323.56 - $450.46
Q3 2016	265,180	$106,608	$398.92	$346.51 - $441.54
Q2 2016	387,180	$135,215	$383.00	$327.27 - $431.54
Q1 2016	402,480	$145,070	$409.79	$347.04 - $529.97
Q4 2015	253,667	$137,708	$538.82	$445.63 - $589.32
Q3 2015	228,497	$106,743	$534.07	$433.12 - $602.59
Q1 2015	480	$217	$421.46	$390.83 - $492.77
Q3 2014	9,480	$3,418	$333.32	$283.49 - $367.27
Q1 2014	6,280	$1,885	$306.39	$261.52 - $350.55
Q4 2013	8,780	$2,417	$286.03	$256.27 - $317.74
Q3 2013	106,180	$33,220	$261.58	$224.53 - $318.07
Q2 2013	188,680	$42,430	$231.58	$176.14 - $282.42