REGULUS THERAPEUTICS INC

CUSIP: 75915K101 Class: COM

PRICE T ROWE ASSOCIATES INC /MD/'s Holding History (CIK: 0000080255)

Note: Option positions (PUT/CALL) are excluded.

Q4 2016
Shares 114,400 Value ($000) $257 Avg Close — Range —
Q3 2016
Shares 114,400 Value ($000) $378 Avg Close — Range —
Q2 2016
Shares 105,600 Value ($000) $305 Avg Close — Range —
Q1 2016
Shares 107,300 Value ($000) $744 Avg Close — Range —
Q4 2015
Shares 125,300 Value ($000) $1,093 Avg Close — Range —
Q3 2015
Shares 119,700 Value ($000) $783 Avg Close — Range —
Q2 2015
Shares 117,900 Value ($000) $1,292 Avg Close — Range —
Q1 2015
Shares 97,200 Value ($000) $1,647 Avg Close — Range —
Q3 2014
Shares 337,567 Value ($000) $2,306 Avg Close — Range —
Q2 2014
Shares 337,159 Value ($000) $2,711 Avg Close — Range —
Q1 2014
Shares 336,599 Value ($000) $3,036 Avg Close — Range —
Q4 2013
Shares 339,115 Value ($000) $2,506 Avg Close — Range —
Q3 2013
Shares 266,590 Value ($000) $2,514 Avg Close — Range —