REGULUS THERAPEUTICS INC

CUSIP: 75915K101 Class: COM

FMR LLC's Holding History (CIK: 0000315066)

Note: Option positions (PUT/CALL) are excluded.

Q3 2018
Shares 3,961,244 Value ($000) $783 Avg Close — Range —
Q2 2018
Shares 15,647,932 Value ($000) $10,315 Avg Close — Range —
Q1 2018
Shares 15,593,865 Value ($000) $11,189 Avg Close — Range —
Q4 2017
Shares 15,593,272 Value ($000) $16,217 Avg Close — Range —
Q3 2017
Shares 15,567,859 Value ($000) $19,460 Avg Close — Range —
Q2 2017
Shares 7,977,349 Value ($000) $7,862 Avg Close — Range —
Q1 2017
Shares 7,939,860 Value ($000) $13,101 Avg Close — Range —
Q4 2016
Shares 7,938,495 Value ($000) $17,862 Avg Close — Range —
Q3 2016
Shares 7,923,048 Value ($000) $26,146 Avg Close — Range —
Q2 2016
Shares 7,917,151 Value ($000) $22,881 Avg Close — Range —
Q1 2016
Shares 7,905,717 Value ($000) $54,787 Avg Close — Range —
Q4 2015
Shares 7,851,397 Value ($000) $68,464 Avg Close — Range —
Q3 2015
Shares 7,787,929 Value ($000) $50,933 Avg Close — Range —
Q2 2015
Shares 7,652,610 Value ($000) $83,873 Avg Close — Range —
Q1 2015
Shares 7,577,511 Value ($000) $128,363 Avg Close — Range —
Q4 2014
Shares 7,290,574 Value ($000) $116,941 Avg Close — Range —
Q3 2014
Shares 6,508,851 Value ($000) $44,455 Avg Close — Range —
Q2 2014
Shares 6,317,134 Value ($000) $50,790 Avg Close — Range —
Q1 2014
Shares 6,314,452 Value ($000) $56,956 Avg Close — Range —
Q4 2013
Shares 6,266,598 Value ($000) $46,310 Avg Close — Range —
Q3 2013
Shares 6,127,652 Value ($000) $57,784 Avg Close — Range —
Q2 2013
Shares 3,909,452 Value ($000) $38,352 Avg Close — Range —