REGULUS THERAPEUTICS INC

CUSIP: 75915K101 Class: COM

CHARLES SCHWAB INVESTMENT MANAGEMENT INC's Holding History (CIK: 0000884546)

Note: Option positions (PUT/CALL) are excluded.

Q1 2017
Shares 61,781 Value ($000) $102 Avg Close — Range —
Q4 2016
Shares 61,781 Value ($000) $140 Avg Close — Range —
Q3 2016
Shares 61,781 Value ($000) $204 Avg Close — Range —
Q2 2016
Shares 61,781 Value ($000) $179 Avg Close — Range —
Q1 2016
Shares 39,681 Value ($000) $275 Avg Close — Range —
Q4 2015
Shares 39,681 Value ($000) $347 Avg Close — Range —
Q3 2015
Shares 39,681 Value ($000) $260 Avg Close — Range —
Q2 2015
Shares 39,681 Value ($000) $435 Avg Close — Range —
Q1 2015
Shares 23,300 Value ($000) $395 Avg Close — Range —
Q4 2014
Shares 18,100 Value ($000) $291 Avg Close — Range —
Q3 2014
Shares 18,100 Value ($000) $124 Avg Close — Range —
Q2 2014
Shares 18,100 Value ($000) $146 Avg Close — Range —
Q1 2014
Shares 18,100 Value ($000) $164 Avg Close — Range —
Q4 2013
Shares 18,100 Value ($000) $134 Avg Close — Range —
Q3 2013
Shares 18,100 Value ($000) $168 Avg Close — Range —
Q2 2013
Shares 18,100 Value ($000) $181 Avg Close — Range —