REGULUS THERAPEUTICS INC

CUSIP: 75915K101 Class: COM

D. E. Shaw & Co., Inc.'s Holding History (CIK: 0001009207)

Note: Option positions (PUT/CALL) are excluded.

Q4 2017
Shares 27,319 Value ($000) $28 Avg Close — Range —
Q3 2017
Shares 29,728 Value ($000) $37 Avg Close — Range —
Q4 2016
Shares 61,881 Value ($000) $139 Avg Close — Range —
Q3 2016
Shares 56,874 Value ($000) $187 Avg Close — Range —
Q1 2016
Shares 68,682 Value ($000) $476 Avg Close — Range —
Q4 2015
Shares 107,267 Value ($000) $935 Avg Close — Range —
Q3 2015
Shares 51,834 Value ($000) $339 Avg Close — Range —
Q1 2015
Shares 12,508 Value ($000) $212 Avg Close — Range —
Q3 2013
Shares 25,411 Value ($000) $240 Avg Close — Range —