REGULUS THERAPEUTICS INC

CUSIP: 75915K101 Class: COM

RA CAPITAL MANAGEMENT, L.P.'s Holding History (CIK: 0001346824)

Note: Option positions (PUT/CALL) are excluded.

Q1 2016
Shares 1,045,119 Value ($000) $7,243 Avg Close — Range —
Q4 2015
Shares 3,482,924 Value ($000) $30,371 Avg Close — Range —
Q3 2015
Shares 4,039,823 Value ($000) $26,420 Avg Close — Range —
Q2 2015
Shares 3,790,476 Value ($000) $41,544 Avg Close — Range —
Q1 2015
Shares 3,590,688 Value ($000) $60,826 Avg Close — Range —
Q4 2014
Shares 4,742,911 Value ($000) $76,076 Avg Close — Range —