REGULUS THERAPEUTICS INC

CUSIP: 75915K101 Class: COM

DAFNA Capital Management LLC's Holding History (CIK: 0001389933)

Note: Option positions (PUT/CALL) are excluded.

Q3 2016

Shares 421,500 Value ($000) $1,391 Avg Close — Range —

Q2 2016

Shares 421,500 Value ($000) $1,218 Avg Close — Range —

Q1 2016

Shares 391,500 Value ($000) $2,713 Avg Close — Range —

Q4 2015

Shares 90,000 Value ($000) $785 Avg Close — Range —

Q3 2015

Shares 90,000 Value ($000) $589 Avg Close — Range —

Period	Shares	Value ($000)	Average Close	Price Range
Q3 2016	421,500	$1,391	—	—
Q2 2016	421,500	$1,218	—	—
Q1 2016	391,500	$2,713	—	—
Q4 2015	90,000	$785	—	—
Q3 2015	90,000	$589	—	—