REGULUS THERAPEUTICS INC

CUSIP: 75915K101 Class: COM

TWO SIGMA SECURITIES, LLC's Holding History (CIK: 0001450144)

Note: Option positions (PUT/CALL) are excluded.

Q3 2018
Shares 17,463 Value ($000) $3 Avg Close — Range —
Q1 2018
Shares 18,963 Value ($000) $14 Avg Close — Range —