REGULUS THERAPEUTICS INC

CUSIP: 75915K101 Class: COM

SIMPLEX TRADING, LLC's Holding History (CIK: 0001488542)

Note: Option positions (PUT/CALL) are excluded.

Q3 2017
Shares 1,108 Value ($000) $1 Avg Close — Range —
Q2 2017
Shares 285 Value ($000) $0 Avg Close — Range —
Q3 2016
Shares 877 Value ($000) $2 Avg Close — Range —
Q1 2016
Shares 14,751 Value ($000) $102 Avg Close — Range —
Q4 2015
Shares 3,481 Value ($000) $30 Avg Close — Range —
Q2 2015
Shares 33,053 Value ($000) $362 Avg Close — Range —
Q1 2015
Shares 600 Value ($000) $10 Avg Close — Range —