REGULUS THERAPEUTICS INC

CUSIP: 75915K200 Class: COM

MANUFACTURERS LIFE INSURANCE COMPANY, THE's Holding History (CIK: 0000928047)

Note: Option positions (PUT/CALL) are excluded.

Q3 2021
Shares 10,610 Value ($000) $7 Avg Close — Range —
Q2 2021
Shares 10,610 Value ($000) $9 Avg Close — Range —