REGULUS THERAPEUTICS INC

CUSIP: 75915K200 Class: COM

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q1 2022
Shares 114,440 Value ($000) $34 Avg Close — Range —
Q4 2021
Shares 55,306 Value ($000) $17 Avg Close — Range —
Q1 2021
Shares 1,070,209 Value ($000) $1,670 Avg Close — Range —
Q4 2020
Shares 29,716 Value ($000) $40 Avg Close — Range —
Q2 2020
Shares 16,332 Value ($000) $11 Avg Close — Range —
Q4 2018
Shares 22,216 Value ($000) $21 Avg Close — Range —