REPLIGEN CORP

Ticker: RGEN CUSIP: 759916109 Class: Common Stock

MANUFACTURERS LIFE INSURANCE COMPANY, THE's Holding History (CIK: 0000928047)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 57,102 Value ($000) $9,409 Avg Close $156.63 Range $134.19 - $174.01

Q3 2025

Shares 47,815 Value ($000) $6,391 Avg Close $121.47 Range $110.77 - $135.57

Q2 2025

Shares 74,000 Value ($000) $9,204 Avg Close $127.25 Range $102.97 - $148.94

Q1 2025

Shares 63,053 Value ($000) $8,023 Avg Close $153.93 Range $125.39 - $182.52

Q4 2024

Shares 64,199 Value ($000) $9,241 Avg Close $143.40 Range $121.52 - $161.24

Q3 2024

Shares 66,667 Value ($000) $9,921 Avg Close $143.39 Range $117.63 - $172.65

Q2 2024

Shares 67,701 Value ($000) $8,534 Avg Close $156.74 Range $113.50 - $184.98

Q1 2024

Shares 64,755 Value ($000) $11,910 Avg Close $190.44 Range $167.40 - $211.13

Q4 2023

Shares 62,639 Value ($000) $11,262 Avg Close $155.67 Range $110.45 - $188.31

Q3 2023

Shares 63,816 Value ($000) $10,147 Avg Close $163.47 Range $134.64 - $181.26

Q2 2023

Shares 56,348 Value ($000) $7,971 Avg Close $160.35 Range $135.37 - $182.42

Q1 2023

Shares 56,066 Value ($000) $9,439 Avg Close $178.42 Range $147.53 - $200.98

Q4 2022

Shares 55,557 Value ($000) $9,428 Avg Close $181.39 Range $158.58 - $225.62

Q3 2022

Shares 54,862 Value ($000) $10,316 Avg Close $210.87 Range $157.33 - $262.26

Q2 2022

Shares 54,530 Value ($000) $8,894 Avg Close $158.16 Range $137.21 - $190.59

Q1 2022

Shares 53,816 Value ($000) $10,127 Avg Close $189.96 Range $156.28 - $265.78

Q4 2021

Shares 124,523 Value ($000) $32,952 Avg Close $269.41 Range $243.29 - $306.98

Q3 2021

Shares 151,915 Value ($000) $43,902 Avg Close $256.54 Range $193.03 - $327.32

Q2 2021

Shares 145,073 Value ($000) $28,960 Avg Close $193.99 Range $162.29 - $223.03

Q1 2021

Shares 123,576 Value ($000) $24,024 Avg Close $205.03 Range $173.09 - $228.84

Q4 2020

Shares 75,188 Value ($000) $14,409 Avg Close $181.94 Range $146.52 - $212.55

Q3 2020

Shares 78,492 Value ($000) $11,581 Avg Close $142.94 Range $120.12 - $159.97

Q2 2020

Shares 77,631 Value ($000) $9,245 Avg Close $117.64 Range $92.00 - $143.93

Q1 2020

Shares 113,248 Value ($000) $10,933 Avg Close $96.54 Range $78.41 - $109.94

Q4 2019

Shares 109,670 Value ($000) $10,144 Avg Close $84.01 Range $72.32 - $93.50

Q3 2019

Shares 113,017 Value ($000) $8,662 Avg Close $87.47 Range $75.80 - $99.25

Q2 2019

Shares 29,223 Value ($000) $2,512 Avg Close $68.16 Range $52.87 - $86.16

Q1 2019

Shares 25,499 Value ($000) $1,506 Avg Close $57.51 Range $49.07 - $63.41

Q4 2018

Shares 24,046 Value ($000) $1,268 Avg Close $58.65 Range $48.26 - $70.50

Q3 2018

Shares 25,466 Value ($000) $1,412 Avg Close $51.54 Range $45.00 - $58.99

Q2 2018

Shares 29,261 Value ($000) $1,376 Avg Close $41.16 Range $34.61 - $47.87

Q1 2018

Shares 28,341 Value ($000) $1,025 Avg Close $35.17 Range $29.56 - $37.82

Q4 2017

Shares 29,042 Value ($000) $1,054 Avg Close $36.20 Range $31.96 - $40.05

Q3 2017

Shares 28,373 Value ($000) $1,087 Avg Close $41.91 Range $35.73 - $46.12

Q2 2017

Shares 26,402 Value ($000) $1,095 Avg Close $38.00 Range $32.73 - $46.81

Q1 2017

Shares 26,296 Value ($000) $926 Avg Close $31.67 Range $28.48 - $35.61

Q4 2016

Shares 23,129 Value ($000) $712 Avg Close $30.93 Range $26.16 - $34.06

Q3 2016

Shares 23,039 Value ($000) $695 Avg Close $30.18 Range $25.93 - $33.79

Q2 2016

Shares 23,065 Value ($000) $631 Avg Close $25.57 Range $21.11 - $28.97

Q1 2016

Shares 21,694 Value ($000) $581 Avg Close $24.47 Range $20.07 - $28.85

Q4 2015

Shares 21,461 Value ($000) $607 Avg Close $28.84 Range $21.69 - $36.00

Q3 2015

Shares 21,235 Value ($000) $592 Avg Close $36.14 Range $27.25 - $42.22

Q2 2015

Shares 20,680 Value ($000) $854 Avg Close $36.64 Range $28.88 - $42.48

Q1 2015

Shares 21,013 Value ($000) $638 Avg Close $25.94 Range $19.53 - $34.15

Q4 2014

Shares 20,441 Value ($000) $405 Avg Close $22.36 Range $19.02 - $26.75

Q3 2014

Shares 21,058 Value ($000) $420 Avg Close $21.05 Range $18.23 - $24.68

Q2 2014

Shares 20,879 Value ($000) $476 Avg Close $17.80 Range $12.60 - $23.14

Q1 2014

Shares 24,359 Value ($000) $314 Avg Close $14.34 Range $11.70 - $17.26

Q4 2013

Shares 25,153 Value ($000) $343 Avg Close $11.94 Range $9.89 - $14.05

Q3 2013

Shares 24,227 Value ($000) $269 Avg Close $9.95 Range $8.25 - $11.44

Q2 2013

Shares 24,242 Value ($000) $200 Avg Close $8.40 Range $6.65 - $9.65

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	57,102	$9,409	$156.63	$134.19 - $174.01
Q3 2025	47,815	$6,391	$121.47	$110.77 - $135.57
Q2 2025	74,000	$9,204	$127.25	$102.97 - $148.94
Q1 2025	63,053	$8,023	$153.93	$125.39 - $182.52
Q4 2024	64,199	$9,241	$143.40	$121.52 - $161.24
Q3 2024	66,667	$9,921	$143.39	$117.63 - $172.65
Q2 2024	67,701	$8,534	$156.74	$113.50 - $184.98
Q1 2024	64,755	$11,910	$190.44	$167.40 - $211.13
Q4 2023	62,639	$11,262	$155.67	$110.45 - $188.31
Q3 2023	63,816	$10,147	$163.47	$134.64 - $181.26
Q2 2023	56,348	$7,971	$160.35	$135.37 - $182.42
Q1 2023	56,066	$9,439	$178.42	$147.53 - $200.98
Q4 2022	55,557	$9,428	$181.39	$158.58 - $225.62
Q3 2022	54,862	$10,316	$210.87	$157.33 - $262.26
Q2 2022	54,530	$8,894	$158.16	$137.21 - $190.59
Q1 2022	53,816	$10,127	$189.96	$156.28 - $265.78
Q4 2021	124,523	$32,952	$269.41	$243.29 - $306.98
Q3 2021	151,915	$43,902	$256.54	$193.03 - $327.32
Q2 2021	145,073	$28,960	$193.99	$162.29 - $223.03
Q1 2021	123,576	$24,024	$205.03	$173.09 - $228.84
Q4 2020	75,188	$14,409	$181.94	$146.52 - $212.55
Q3 2020	78,492	$11,581	$142.94	$120.12 - $159.97
Q2 2020	77,631	$9,245	$117.64	$92.00 - $143.93
Q1 2020	113,248	$10,933	$96.54	$78.41 - $109.94
Q4 2019	109,670	$10,144	$84.01	$72.32 - $93.50
Q3 2019	113,017	$8,662	$87.47	$75.80 - $99.25
Q2 2019	29,223	$2,512	$68.16	$52.87 - $86.16
Q1 2019	25,499	$1,506	$57.51	$49.07 - $63.41
Q4 2018	24,046	$1,268	$58.65	$48.26 - $70.50
Q3 2018	25,466	$1,412	$51.54	$45.00 - $58.99
Q2 2018	29,261	$1,376	$41.16	$34.61 - $47.87
Q1 2018	28,341	$1,025	$35.17	$29.56 - $37.82
Q4 2017	29,042	$1,054	$36.20	$31.96 - $40.05
Q3 2017	28,373	$1,087	$41.91	$35.73 - $46.12
Q2 2017	26,402	$1,095	$38.00	$32.73 - $46.81
Q1 2017	26,296	$926	$31.67	$28.48 - $35.61
Q4 2016	23,129	$712	$30.93	$26.16 - $34.06
Q3 2016	23,039	$695	$30.18	$25.93 - $33.79
Q2 2016	23,065	$631	$25.57	$21.11 - $28.97
Q1 2016	21,694	$581	$24.47	$20.07 - $28.85
Q4 2015	21,461	$607	$28.84	$21.69 - $36.00
Q3 2015	21,235	$592	$36.14	$27.25 - $42.22
Q2 2015	20,680	$854	$36.64	$28.88 - $42.48
Q1 2015	21,013	$638	$25.94	$19.53 - $34.15
Q4 2014	20,441	$405	$22.36	$19.02 - $26.75
Q3 2014	21,058	$420	$21.05	$18.23 - $24.68
Q2 2014	20,879	$476	$17.80	$12.60 - $23.14
Q1 2014	24,359	$314	$14.34	$11.70 - $17.26
Q4 2013	25,153	$343	$11.94	$9.89 - $14.05
Q3 2013	24,227	$269	$9.95	$8.25 - $11.44
Q2 2013	24,242	$200	$8.40	$6.65 - $9.65