SAREPTA THERAPEUTICS INC

Ticker: SRPT CUSIP: 803607100 Class: Common Stock

TWO SIGMA INVESTMENTS, LP's Holding History (CIK: 0001179392)

Note: Option positions (PUT/CALL) are excluded.

Q4 2025

Shares 2,441,455 Value ($000) $52,540 Avg Close $21.08 Range $15.08 - $25.32

Q3 2025

Shares 2,137,764 Value ($000) $41,195 Avg Close $17.83 Range $10.42 - $22.86

Q2 2025

Shares 2,161,697 Value ($000) $36,965 Avg Close $42.66 Range $16.96 - $65.69

Q1 2025

Shares 550,880 Value ($000) $35,157 Avg Close $105.27 Range $62.50 - $129.84

Q4 2024

Shares 75,054 Value ($000) $9,126 Avg Close $122.55 Range $102.16 - $138.81

Q3 2024

Shares 202,270 Value ($000) $25,262 Avg Close $138.24 Range $120.42 - $162.95

Q2 2024

Shares 541,794 Value ($000) $85,603 Avg Close $128.46 Range $109.91 - $173.25

Q1 2024

Shares 342,682 Value ($000) $44,364 Avg Close $122.50 Range $91.34 - $143.00

Q4 2023

Shares 302,340 Value ($000) $29,155 Avg Close $95.93 Range $55.25 - $125.00

Q3 2023

Shares 810,467 Value ($000) $98,245 Avg Close $113.03 Range $100.73 - $124.51

Q2 2023

Shares 1,289,198 Value ($000) $147,639 Avg Close $128.81 Range $105.04 - $159.89

Q1 2023

Shares 1,097,143 Value ($000) $151,219 Avg Close $129.72 Range $116.10 - $159.84

Q4 2022

Shares 691,406 Value ($000) $89,592 Avg Close $115.88 Range $100.15 - $134.08

Q3 2022

Shares 789,712 Value ($000) $87,295 Avg Close $100.79 Range $72.02 - $120.23

Q2 2022

Shares 30,667 Value ($000) $2,299 Avg Close $73.57 Range $61.28 - $89.55

Q1 2022

Shares 293,299 Value ($000) $22,913 Avg Close $76.58 Range $61.31 - $92.00

Q4 2021

Shares 806,261 Value ($000) $72,604 Avg Close $85.49 Range $75.80 - $101.24

Q3 2021

Shares 252,376 Value ($000) $23,340 Avg Close $77.03 Range $65.30 - $93.50

Q2 2021

Shares 20,967 Value ($000) $1,630 Avg Close $75.81 Range $67.68 - $90.00

Q1 2021

Shares 86,267 Value ($000) $6,429 Avg Close $92.28 Range $69.56 - $174.49

Q1 2018

Shares 56,203 Value ($000) $4,164 Avg Close $66.68 Range $50.68 - $84.37

Q4 2016

Shares 263,229 Value ($000) $7,220 Avg Close $40.16 Range $26.66 - $63.03

Q4 2015

Shares 115,518 Value ($000) $4,457 Avg Close $32.42 Range $23.09 - $41.97

Q3 2015

Shares 89,267 Value ($000) $2,866 Avg Close $33.93 Range $28.19 - $41.47

Period	Shares	Value ($000)	Average Close	Price Range
Q4 2025	2,441,455	$52,540	$21.08	$15.08 - $25.32
Q3 2025	2,137,764	$41,195	$17.83	$10.42 - $22.86
Q2 2025	2,161,697	$36,965	$42.66	$16.96 - $65.69
Q1 2025	550,880	$35,157	$105.27	$62.50 - $129.84
Q4 2024	75,054	$9,126	$122.55	$102.16 - $138.81
Q3 2024	202,270	$25,262	$138.24	$120.42 - $162.95
Q2 2024	541,794	$85,603	$128.46	$109.91 - $173.25
Q1 2024	342,682	$44,364	$122.50	$91.34 - $143.00
Q4 2023	302,340	$29,155	$95.93	$55.25 - $125.00
Q3 2023	810,467	$98,245	$113.03	$100.73 - $124.51
Q2 2023	1,289,198	$147,639	$128.81	$105.04 - $159.89
Q1 2023	1,097,143	$151,219	$129.72	$116.10 - $159.84
Q4 2022	691,406	$89,592	$115.88	$100.15 - $134.08
Q3 2022	789,712	$87,295	$100.79	$72.02 - $120.23
Q2 2022	30,667	$2,299	$73.57	$61.28 - $89.55
Q1 2022	293,299	$22,913	$76.58	$61.31 - $92.00
Q4 2021	806,261	$72,604	$85.49	$75.80 - $101.24
Q3 2021	252,376	$23,340	$77.03	$65.30 - $93.50
Q2 2021	20,967	$1,630	$75.81	$67.68 - $90.00
Q1 2021	86,267	$6,429	$92.28	$69.56 - $174.49
Q1 2018	56,203	$4,164	$66.68	$50.68 - $84.37
Q4 2016	263,229	$7,220	$40.16	$26.66 - $63.03
Q4 2015	115,518	$4,457	$32.42	$23.09 - $41.97
Q3 2015	89,267	$2,866	$33.93	$28.19 - $41.47